President Joe Biden will reveal details on new actions against illicit drugs and more access to mental health care, as well as advocate for the reauthorization of the National Cancer Act in his second State of the Union address.
The speech is expected to highlight last year's "unity agenda" on issues that lawmakers and the public could unite around regardless of political affiliation.
The President's administration has made nearly 30 federal programs, policies and resources for cancer care, and Mr Biden's speech will discuss bringing the US's cancer research and care systems into the 21st century.
In his second State of the Union address, President Biden is expected to outline new steps to tackle illegal drugs and bolster access to mental health care.
Additionally, he is calling on Congress to reauthorize the National Cancer Act, a law that established the National Cancer Institute, as well as provide new funding for cancer research.
According to aides, Mr Biden will call for a "forceful approach" in the fight against fentanyl and for expanding public health resources to reduce drug overdose deaths.
White House Cancer Moonshot Coordinator Danielle Carnival said that the speech will cover the administration's progress towards "bringing America's cancer research and care systems into the 21st century", including new federal programs and policies from the first-ever cancer cabinet.
The speech aims to unite lawmakers and the American public on the issues of drug policy, mental health care, and cancer research.
Parts of the address will discuss the Biden administration's commitment to levelling the playing field for Black, Latino, Native Americans, and rural communities that have been significantly affected by the drug epidemic.
Aides say the President's message will urge Congress to reauthorize the National Cancer Act and allocate funding to tackle cancer care and research.
A bipartisan bill passed in 2016, the 21st Century Cures Act, may expire this year, and the President is advocating for Congress to update and reauthorize it.
The speech, according to its aides, aims to show Mr Biden's drive to enact bipartisan policies, with the goal of upscaling cancer research, mental health care, and drug policy initiatives across the United States, regardless of political affiliation.