Harris Associates, the Chicago-based investment firm, has sold its 10% stake in Credit Suisse.
The firm's Deputy Chairman, David Herro, confirmed that they had completed the sale, which he said he wished had been done sooner.
Harris Associates, the investment company behind the Oakmark fund range, is no longer Credit Suisse's biggest investor.
This brings to a close negotiations that began in November around a potential breakout of the US investment firm's stake.
Although analysts described the move as "predictable", Credit Suisse's efforts to curtail Harris didn't escape wide attention, and the two parties were said to be at odds over a number of issues.
It is clear that relationships had soured between the lender and Herro's Chicago-based firm, which has taken a big hit on the stake since the financial crisis.
Critics have argued that Harris' investment in Credit Suisse was misguided, given the bank's troubles over the past five years.
In his comments on the matter, Herro acknowledged this, saying it had been "a long, painful ride" with Credit Suisse.
"I wish it had been two or three years earlier - but better late than never," he said.
Analysts predict that the sale is an obvious move given Harris' poor recent returns among its mutual funds, and expect the proceeds to go back to investors rather than to be reinvested in another company.
Despite Credit Suisse announcing cost cuts of CHF 4.3bn ($4.4bn) by the end of 2018, shares in the bank have slipped close to 30 percent so far this year.